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pentobarbital will minimize the extent or result of fentanyl intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to a lessen in fentanyl plasma concentrations, deficiency of efficacy or, probably, enhancement of the withdrawal syndrom